Progesterone-Only Pills and Heart Palpitations: What You Need to Know

Published on February 18, 2025

Key Takeaway

While progesterone-only pills are generally considered safe for cardiovascular health, some women may experience heart palpitations as a side effect, though the risk appears to be lower compared to combined hormonal contraceptives.

Introduction

For many women, choosing the right contraceptive method involves carefully weighing the benefits against potential side effects. One concern that often arises is the impact of hormonal contraceptives on heart health, particularly the occurrence of heart palpitations. This article delves into the relationship between progesterone-only pills (POPs) and heart palpitations, providing you with the latest research and expert insights.

Understanding Progesterone-Only Pills

Progesterone-only pills, also known as the 'mini-pill,' are a form of oral contraception that contains only synthetic progesterone (progestin) without estrogen. These pills are often recommended for women who cannot take estrogen-containing contraceptives due to various health reasons.

A close-up of progesterone-only birth control pills in a blister pack

Progesterone-Only Pills and Cardiovascular Health

When it comes to cardiovascular health, progesterone-only pills are generally considered safer than combined hormonal contraceptives. A study by L A Heinemann et al. (1999) found that the risk of cardiovascular disease associated with progestogen-only pills was not significantly increased. The adjusted odds ratios for myocardial infarction, thromboembolic cerebrovascular accidents, and venous thromboembolism were 0.94, 1.60, and 0.68, respectively, indicating no convincing evidence for increased cardiovascular risk.

Heart Palpitations and Hormonal Contraceptives

Heart palpitations are sensations of a rapid or irregular heartbeat. While they can be concerning, they're often harmless. However, it's essential to understand their potential relationship with hormonal contraceptives:

  • Combined hormonal contraceptives have been associated with a slight increase in heart palpitations due to their estrogen content.
  • Progesterone-only pills, lacking estrogen, are generally thought to have a lower risk of causing palpitations.
  • Individual responses can vary, and some women may still experience palpitations with POPs.

Research on Progesterone and Heart Function

Interestingly, some research suggests that progesterone might have protective effects on the heart. A study by James E Tisdale et al. (2019) found that progesterone pretreatment reduced the incidence of drug-induced torsades de pointes (a type of irregular heartbeat) in rabbit hearts. This suggests that progesterone might have some cardioprotective properties.

A medical heart monitor displaying a normal sinus rhythm

Potential Side Effects of Progesterone-Only Pills

While progesterone-only pills are generally well-tolerated, they can cause some side effects. According to Healthline, the most common side effects of progesterone-only pills include:

  • Unscheduled or irregular menstrual bleeding
  • Acne flareups
  • Increased risk of follicular ovarian cysts

It's important to note that heart palpitations are not listed among the common side effects, but individual experiences may vary.

When to Seek Medical Advice

If you're experiencing persistent or concerning heart palpitations while taking progesterone-only pills, it's crucial to consult your healthcare provider. They can help determine if the palpitations are related to your contraception or if there's another underlying cause.

Conclusion

While progesterone-only pills are generally considered a safer option for women with cardiovascular risk factors, the relationship between POPs and heart palpitations is complex and can vary among individuals. Current research suggests that POPs have a lower risk of cardiovascular side effects compared to combined hormonal contraceptives. However, as with any medication, it's essential to discuss your personal health history and concerns with your healthcare provider to determine the best contraceptive option for you.